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Journal of Parathyroid Disease 2013;1(2):17-20
Impact of vitamin D on the immune system in kidney disease

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Mohammad-Reza Ardalan 1, Houshang Sanadgol 2, Hamid Nasri 3, Azar Baradaran 4, Mohammad-Reza Tamadon 5, Mahmoud Rafieian-Kopaei 6 *

1 Chronic Kidney Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Department of Nephrology, Zahedan University of Medical Sciences, Zahedan, Iran.
3 Department of Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran.
4 Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.
5 Department of Nephrology, Semnan University of Medical Sciences, Semnan, Iran.
6 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.


*Corresponding author: Prof. Mahmoud Rafieian-kopaei,
Email: rafieian@yahoo.com


Abstract
When chronic kidney disease progresses, the capability to compensate for elevation in parathyroid hormone and fibroblast growth factor-23 and for decrease in 1,25(OH)2D3 become insufficient, which consequences in high serum phosphorus level, extra-skeletal calcification and abnormal bone disorders. Further to its effect on the regulation of parathyroid hormone, calcium and phosphate, vitamin D has various other non-calciotropic efficacies, comprising controlling cell proliferation/differentiation and having immunomodulatory properties. There are various immune disturbances that can be observed when function deteriorates. It is necessary to understand well both the classical and non-classical functions of vitamin D.

Notes

Implication for health policy/practice/research/ medical education

When chronic kidney disease progresses, the capability to compensate for elevation in parathyroid hormone and fibroblast growth factor-23 and for decrease in 1,25(OH)2D3 become insufficient, which consequences in high serum phosphorus level, extra-skeletal calcification and abnormal bone disorders. Further to its effect on the regulation of parathyroid hormone, calcium and phosphate, vitamin D has various other non-calciotropic efficacies, comprising controlling cell proliferation/differentiation and having immunomodulatory properties. There are various immune disturbances that can be observed when function deteriorates. It is necessary to understand well both the classical and non-classical functions of vitamin D.

Please cite this paper as: Ardalan MR, Sanadgol H, Nasri H, Baradaran A, Tamadon MR, Rafieian-Kopaei R. Impact of vitamin D on the immune system in kidney disease. J Parathyr Dis 2013; 1(2): 17-20.


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