eISSN: 2345-6558

Free Access

Journal of Parathyroid Disease 2018;6(1):13-15 doi: 10.15171/jpd.2018.05
Serum magnesium in association with parathyroid hormone levels in routine hemodialysis patients

Original

Milad Fooladgar 1, Afsaneh Malekpour 2, Shahin Asgari-Savadjani 3, Saeed Mardani 4 *

1 Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
2 Department of Community Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran


*Corresponding author: Saeed Mardani,
Email: Dr_s_mardani@yahoo.com


Abstract

Introduction: The homeostasis of magnesium (Mg) is perturbed in chronic kidney disease. It has been supposed that plasma Mg has a principal role to regulate the secretion of parathyroid hormone (PTH). Plasma Mg is capable of modulating secretion of PTH. Recent investigations showed that low serum Mg levels in patients with kidney disease have been linked to increased mortality.

Objectives: The aim of this study was to determine the relationship between serum Mg and PTH levels in hemodialysis patients.

Patients and Methods: This cross-sectional study was conducted on 56 hemodialysis patients in hemodialysis center of Hajar hospital of Shahrekord in 2015. Regular hemodialysis patients who had at least three months history of dialysis were enrolled to the study. The serum levels of Mg, calcium, phosphorus, intact PTH (iPTH), alkaline phosphatase, albumin and bicarbonate were measured.

Results: In this study, 61.5% of the 52 patients were male. Mean ± standard deviation (SD) of patients’ age was 60.5 ± 17.7 years with median of 63 years old. The average duration of dialysis was 44±39.5 months (median 36 months). Additionally the dialysis dose was 517 ± 479 weeks (median; 414 weeks). Mean ± SD of serum iPTH and Mg were 360.1 ± 238.2 pg/mL and 2.2 ± 0.2 mg/mL respectively. In this study we found a significantly positive correlation of iPTH with serum Mg levels (r=0.28, P=0.04).

Conclusion: This study shows impact of Mg on parathormone secretion. Our findings require further investigations with larger and multicentric studies. 



Notes

Please cite this paper as: Fooladgar M, Malekpour A, Asgari-Savadjani S, Mardani S. Serum magnesium in association with parathyroid hormone levels in routine hemodialysis patients. J Parathyr Dis. 2018;6(1):13-15. DOI: 10.15171/jpd.2018.05.

Copyright © 2018 The Author(s); Published by Nickan Research Institute. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.​


Comments
First name  
Last name  
Email address  
Comments  
Security code



Article
PDF


Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks

Cite by
Google Scholar

Google Scholar
Articles by Milad Fooladgar
Articles by Afsaneh Malekpour
Articles by Shahin Asgari-Savadjani
Articles by Saeed Mardani
Similar articles
Related articles

PubMed
Articles by Milad Fooladgar
Articles by Afsaneh Malekpour
Articles by Shahin Asgari-Savadjani
Articles by Saeed Mardani


Article Access Statistics
Viewed
PDF Downloaded
Comments

Share this article!
Creative Commons Attribution 4.0 License This work is licensed under a Creative Commons Attribution 4.0 License.
Copyright © 2016 The Author(s)
Published by Nickan Research Institute