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J parathyr dis. 2014;2(2): 75-77.
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Hypothesis

Beyond the phosphate binding effect of sevelamer; bright pleiotropic properties in renal failure and dialysis patients

Mahmoud Rafieian-Kopaei 1, Saeed Mardani 2, Hamid Nasri 3*, Seyed Seifollah Beladi Mousavi 4

1 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
2 Department of Nephrology, Shahrekord University of Medical Sciences, Shahrekord, Iran.
3 Department of Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran.
4 Department of Internal Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
*Corresponding author: Prof. Hamid Nasri, hamidnasri@yahoo.com

Implication for health policy/practice/research/medical education

In addition to its labeled property of serum phosphate reduction in hemodialysis individuals, sevelamer may have further effects on factors influencing vascular endothelium, like inhibition of progression of vascular calcification, reduction of fibroblast growth factor 23, abolishing of circulating inflammatory and oxidative molecules, reducing of total and LDL cholesterol, uric acid, and uremic toxins. Also sevelamer may reduce blood absorption of advanced glycation end products and endotoxins from the intestine. Hence, it is affordable to suggest that endothelial pleiotropic effects of sevelamer may have related to the diminished mortality observed in various studies.

Please cite this paper as: Rafieian-Kopaei M, Mardani S, Nasri H, Beladi Mousavi SS. Beyond the phosphate binding effect of sevelamer; bright pleiotropic properties in renal failure and dialysis patients. J Parathyr Dis 2014; 2(2): 75-77.

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ePublished: 03 Aug 2014
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