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J parathyr dis. 2015;3(1): 20-24.
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Correlation of serum adiponectin level with some biochemical and metabolic factors in stable hemodialysis patients

Mohammad-Reza Tamadon 1, Maryam Heidari 2, Fatemeh Dris 2, Saeed Mardani 2*

1 Department of Internal Medicine, Semnan University of Medical Science, Semnan, Iran.
2 Department of Internal Medicine, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
*Corresponding author: Saeed Mardani, dr_s_mardani@yahoo.com

Abstract

Introduction: Serum adiponectin is a hormone secreted by the adipose tissue and its level usually increases in patients with renal insufficiency. In uremic condition, it not only loses its protective role against atherosclerosis, but also becomes a risk factor. This hormone is a direct predictor of cardiovascular complications in patients with renal failure.

Objectives: This study was designed to assess the association between serum adiponectin with various parameters in in a group of non-diabetic hemodialysis patients.

Patients and Methods: In this study, 73 hemodialysis non-diabetic patients were selected and fasting blood samples were taken to measure adiponectin and some other biochemical parameters. Waist circumference, abdominal circumference, weight and body mass index (BMI) were measured. Pearson statistical test was used to find the association between adiponectin and mentioned parameters.

Results: Adiponectin level was negatively and significantly associated with weight (P < 0.001), BMI (P < 0.001), waist circumference (P < 0.05), abdominal circumference (P < 0.01), and triglycerides (P < 0.01).

Conclusion: According to the results of our study, serum adiponectin level in hemodialysis patients was negatively associated with weight and BMI which indicates the likely effect of the hormone. As a result, finding of exact connections between this cytokines and the risk factors of atherosclerosis and hypercatabolism may help to introduce serum adiponectin as a measurable and important marker for atherosclerosis and may be used as an index for prognosis of mortality in this type of patients.

Keywords: Adiponectin, Kidney failure, Hemodialysis

Implication for health policy/practice/research/ medical education

Adiponectin is a hormone secreted by adipose tissue. In uremic condition, it not only loses its protective role against atherosclerosis, but also becomes a risk factor. It can influence other risk factors for atherosclerosis and can also cause and exacerbate the hypercatabolic condition. Consequently it can result in indiscriminate use of body energy – protein and can be a predictor of morbidity and mortality in these patients. As a result, finding of exact connections between this cytokines and the risk factors of atherosclerosis and hypercatabolism may help to introduce serum adiponectin as a measurable and important marker for atherosclerosis and may be used as an index for prognosis of mortality in this type of patients.   

Please cite this paper as: Tamadon MR, Heidari M, Dris F, Mardani S. Correlation of serum adiponectin level with some biochemical and metabolic factors in stable hemodialysis patients. J Parathyr Dis 2015;3(1):20-24.

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ePublished: 21 Feb 2015
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