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J parathyr dis. 2018;6(1): 19-22.
doi: 10.15171/jpd.2018.07
  Abstract View: 108
  PDF Download: 65

Original

Therapeutic impact of cholecalciferol in patients with psychiatric disorders receiving olanzapine

Somayeh Kaviyani 1 * , Mohammad Bahadoram 2, Gholamreza Houshmand 3, Samaneh Bahadoram 2

1 Department of Psychiatry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Medical Student Research Committee, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
3 Department of Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
*Corresponding author: Somayeh Kaviyani, Kaviyani.s@ajums.ac.ir

Abstract

Introduction: Psychiatric disorders such as schizophrenia require appropriate treatment. Second-generation antipsychotics, including olanzapine, are administered as an appropriated treatment for these disorders. However, this drug has several complications, such as obesity and increased waist circumference which reduces the acceptance of the treatment.

Objectives: The aim of this study was to investigate the effects of vitamin D3 therapy on waist circumference caused by olanzapine. Patients and Methods: In this randomized clinical trial, 50 hospitalized women with psychiatric disorders receiving olanzapine were divided into two groups of intervention and control groups. Before the intervention, the waist circumference, hip circumference, and waist-hip ratio were measured. Then, for 12 weeks, the intervention group received vitamin D3 and the control group received paraffin as the placebo, one pearl every 2 weeks. Waist circumference, hip circumference, and waist-hip ratio were re-measured and the collected data were analyzed by pair t test.

Results: Our findings showed that there is a significant decrease in waist circumference and waist-hip ratio in intervention group (P<0.001). However, these changes were not significant in the placebo group. Hip circumference was not changed significantly in both groups.

Conclusion: Vitamin D can be administered concomitant with 0lanzapine to improve side effects of olanzapine such as increasing waist circumference.

Keywords: Olanzapine, Vitamin D3, Waist circumference, Waist-hip ratio, Psychiatric disorders

Please cite this paper as: Kaviyani S, Bahadoram M, Houshmand G, Bahadoram S. Therapeutic impact of cholecalciferol in patients with psychiatric disorders receiving olanzapine. J Parathyr Dis. 2018;6(1):19-22. DOI: 10.15171/jpd.2018.07

Copyright © 2018 The Author(s); Published by Nickan Research Institute. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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ePublished: 11 Sep 2017
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