J parathyr dis. 2021;9(1): e05.
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Relationship between vitamin D levels in mother’s blood and neonatal umbilical cord with jaundice in neonates

Zahra Sadr* ORCID logo, Mona Nourbakhsh ORCID logo, Majid Bakhshizade ORCID logo, Forough Mokhtari ORCID logo, Maryam Biglari Abhari ORCID logo


Introduction: In neonates, jaundice is the result of an imbalance between the production and conjugation of bilirubin. Overall, about 60% of full-term neonates experience jaundice in the first week of life. Objectives: This study may help to explain preventive methods. We evaluated the relationship between serum levels of vitamin D in the mother's blood and the baby's umbilical cord with the occurrence of neonatal jaundice. Patients and Methods: This prospective study (cohort) was performed on 110 mothers and their newborns in Firoozabadi hospital in Shahr-e Ray. The sampling method was non-probability convenience. Data include maternal age, nationality, gravidity, gestational age, maternal diseases such as chronic liver and kidney disease, diabetes mellitus, hypertension and the use of anticonvulsant drugs. Maternal blood samples during labor and neonatal umbilical cord samples was used for laboratory tests. Neonates visited for jaundice on days 7 and 14 after birth and tested for bilirubin levels if jaundice was observed Results: There was no significant difference between neonates with normal and abnormal vitamin D levels in terms of jaundice on day 7 (P = 0.571). There was not a significant relationship between mothers with normal and abnormal vitamin D levels in terms of jaundice on day 7 in their neonates (P = 0.587). However, a statistically significant relationship between normal vitamin D levels in mothers with jaundice in their neonates on day 14 (P = 0.003) was detected. There was a significant relationship between normal maternal vitamin D with the incidence of neonatal jaundice on day 14(Relative Risk = 0.32).Evaluation of the relationship between normal and abnormal vitamin D levels in neonates with 14th day jaundice revealed no statistically significant relationship between the two groups of normal and abnormal (P = 0.1). First minute Apgar score in neonates who had no jaundice or developed mild jaundice was significantly higher than neonates with severe jaundice (bilirubin > 15mg/dl) (p = 0.026). Conclusion: Overall, no significant relationship was observed between neonatal 7th day jaundice with maternal and neonatal vitamin D levels. There was a significant relationship between maternal normal serum vitamin D levels with neonatal 14th day jaundice.
Keywords: Neonatal Jaundice, Pregnancy, Vitamin D, Bilirubin
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Abstract View: 82

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Submitted: 14 Nov 2020
Accepted: 29 Dec 2020
ePublished: 25 Jan 2021
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