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J Parathyr Dis. 2020;8: e11168.
  Abstract View: 403
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Review

Metformin and thyroid; a narrative review to current concepts

Zeinab Rezvani, Hamid Nasri* ORCID logo

1 Nickan Research Institute, Isfahan, Iran
*Corresponding Author: *Corresponding author: Prof. Hamid Nasri, Email: hamidnasri@yahoo.com, hamidnasri@med.mui.ac.ir, Email: hamidnasri@yahoo.com

Abstract

Metformin has different metabolic effects on diverse tissues through various pathways such as hypothalamic-pituitary-thyroid axis. It is shown that metformin influence on thyroid structure considerably and reduced nodule volume by 30-50% of the first volume in diabetic patients. Besides, metformin shows anti-mitogenic and proapoptotic properties in thyroid cancer cells and enhances the antitumor effect of chemotherapeutic drugs. It prevents cancer growth by reduction of hyperinsulinemia too.

Please cite this paper as: Rezvani Z, Nasri H. Metformin and thyroid; a narrative review to current concepts. J Parathyr Dis. 2020;8:e11168.
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Submitted: 14 Jul 2020
Accepted: 07 Oct 2020
ePublished: 25 Oct 2020
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