J Parathyr Dis. 2023;11: e11203.
doi: 10.34172/jpd.2023.11203
  Abstract View: 519
  PDF Download: 443

Letter to Editor

Hypocalcemia in thalassemia major patients requires an extra-careful approach

Mohammad Bahadoram 1 ORCID logo, Bijan Keikhaei 2 ORCID logo, Mohammad Davoodi 2, Najmeh Nameh Goshay Fard 2, Pouria Ghiasi 2, Esma'il Akade 2* ORCID logo

1 Department of Neurology, School of Medicine, Musculoskeletal Rehabilitation Research Center, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
*Corresponding Author: Esma’il Akade, Email: eakadeh@gmail.com and , Email: akade.se@ajums.ac.ir


Thalassemia is a hematological disorder caused by a gene mutation that leads to defective synthesis of hemoglobin complex. One of the complications of thalassemia is hypocalcemia which is presented with paresthesia, muscle spasm, low-serum calcium, and intracranial calcification. Hypocalcemia can affect thalassemic patients via various mechanisms. Blood transfusion-related and transfusion-independent iron overload, drug side effects, vitamin D3 deficiency, and genetic disorders and polymorphisms are among the etiologies of hypocalcemia in major thalassemia. A careful approach to the differential etiology of this phenomenon is crucial for a resultful treatment.
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Submitted: 17 Mar 2022
Accepted: 12 May 2023
ePublished: 04 Jul 2023
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