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J Parathyr Dis. 2023;11: e11204.
doi: 10.34172/jpd.2023.11204
  Abstract View: 561
  PDF Download: 536

Case Report

Sonidegib induced rhabdomyolysis in kidney transplant patient: a case report

Sonila Mocka 1* ORCID logo, Stefano Ferraro 2, Michela Ardini 1, Michele Marchini 1, Laura Panaro 1, Matteo Trezzi 1, Davide Rolla 1

1 Department of Internal Medicine, Nephrology and Dialysis, Sant’ Andrea Hospital, La Spezia, Italy
2 Department of Internal Medicine, Nephrology and Dialysis, San Paolo Hospital, Savona, Italy
*Corresponding Author: Sonila Mocka, Email: sonila_mocka@hotmail.it, , Email: sonila.mocka83@gmail.com

Abstract

Kidney transplant recipients (KTR) have a higher risk of developing malignancies compared to the general population, due to the immunosuppressive regimens which can promote the oncogenesis process. The incidence of de novo non-melanoma skin cancer (NMSC) in KTR is greater than in the general population. Basal cell carcinoma (BCC) represents one of the most frequent malignancies in KTR. Sonidegib is a Hedgehog signaling pathway inhibitor approved for the treatment of locally advanced basal-cell carcinoma (LABCC) that following surgery or radiation therapy, or is given to those candidates who are not eligible to surgery or radiation therapy. This paper reports the case of a kidney transplant patient, who developed severe acute kidney injury (AKI) due to rhabdomyolysis (RML) induced by sonidegib therapy which required renal replacement therapy (RRT).

Please cite this paper as: Mocka S, Ferraro S, Ardini M, Marchini M, Panaro L, Trezzi M, Davide Rolla D. Sonidegib induced rhabdomyolysis in kidney transplant patient: a case report. J Parathyr Dis. 2023;11:e11204. doi:10.34172/jpd.2023.11204.
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Submitted: 17 Apr 2023
Accepted: 05 Jun 2023
ePublished: 04 Jul 2023
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