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J Parathyr Dis. 2024;12: e11242.
doi: 10.34172/jpd.2023.11242
  Abstract View: 491
  PDF Download: 339

Review

Denosumab for osteoporosis in patients suffering from chronic kidney disease; a review on current data

Fateme Sharafeddin 1 ORCID logo, Sasan Zandi Esfahan 1* ORCID logo, Reza Keshavarz 1 ORCID logo, Golnaz Goudarzi 1 ORCID logo

1 Clinical Research Development Center, Najafabad Branch, Islamic Azad University, Najafabad, Iran
*Corresponding Author: Sasan Zandi Esfahan, Email: Sasanzandiesfahan@yahoo.com

Abstract

Osteoporosis is one of the complications that affects patients with chronic kidney disease (CKD). To treat this complication, denosumab is one of the prescription drugs. We investigated articles with the keywords of “CKD” OR “Chronic Kidney Disease” AND “Denosumab” in the title in PubMed database. Evidence shows the advantages of using denosumab over bisphosphonate in CKD patients. Also, some studies stated that this drug does not have a negative effect on kidney function and its effectiveness is the same in people with different kidney function. The common complication of taking this drug is hypocalcemia, which can be controlled with appropriate approaches in these patients. It is also important to pay attention to adherence and continuity of medication. Some studies also stated that this drug is contraindicated in CKD patients (stage 4 and 5).

Please cite this paper as: Sharafeddin F, Zandi Esfahan S, Keshavarz R, Goudarzi G. Denosumab for osteoporosis in patients suffering from chronic kidney disease; a review on current data. J Parathyr Dis. 2024;12:e11242. doi:10.34172/jpd.2023.11242.
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Submitted: 26 Aug 2023
Accepted: 20 Oct 2023
ePublished: 24 Dec 2023
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