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J Parathyr Dis. 2024;12: e11243.
doi: 10.34172/jpd.2023.11243
  Abstract View: 643
  PDF Download: 321

Case Report

Urinary tract infection triggering hypercalcemic crisis in an asymptomatic patient with primary hyperparathyroidism

Faiz Mohamed 1 ORCID logo, Pichen Shihabudheen 1 ORCID logo, Mohammed Javad Kotta Veluthedathu 1 ORCID logo, Muhammed Unais Thattaril 2 ORCID logo, Nalakath Arakkal Uvais 3* ORCID logo

1 Department of Critical Care, Iqraa International Hospital and Research Centre, Calicut, India
2 Department of Surgery, Iqraa International Hospital and Research Centre, Calicut, India
3 Department of Health Research and Psychiatry, Iqraa International Hospital and Research Centre, Calicut, India
*Corresponding Author: Nalakath Arakkal Uvais, Email: druvaisna@gmail.com

Abstract

Hypercalcemic crisis (HC) is a rare and severe complication of primary hyperparathyroidism (PHPT), characterized by markedly elevated serum calcium levels and diverse clinical manifestations. PHPT is the primary cause of hypercalcemia and is often asymptomatic. The factors that trigger HC in PHPT are not fully understood. Here we report a patient who was diagnosed with HC resulting from previously undetected PHPT. Remarkably, the patient exhibited no symptoms of PHPT before the HC episode. The patient presented with neurological symptoms, including altered behavior and slurred speech, which were attributed to hypercalcemia. The probable trigger for HC in this case appears to be an acute febrile illness related to a urinary tract infection (UTI). The occurrence of an acute febrile illness or UTI as a precipitating factor for HC in PHPT is a rare and infrequently documented phenomenon in the existing medical literature.

Please cite this paper as: Mohamed F, Shihabudheen P, Kotta Veluthedathu MJ, Unais Thattaril M, Arakkal Uvais N. Urinary tract infection triggering hypercalcemic crisis in an asymptomatic patient with primary hyperparathyroidism. J Parathyr Dis. 2024;12:e11243. doi:10.34172/jpd.2023.11243.
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Submitted: 01 Oct 2023
Accepted: 15 Nov 2023
ePublished: 24 Dec 2023
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