J Parathyr Dis. 2024;12: e11256.
doi: 10.34172/jpd.2024.11256
  Abstract View: 196
  PDF Download: 149


Clinical administration of cinacalcet in parathyroid diseases

Azadeh Khayyat 1* ORCID logo, Mohammad Ali Esmaeil Pour 2 ORCID logo

1 Department of Pathology, Resident Physician, Medical College of Wisconsin, Milwaukee, WI, USA.
2 Internist, Rutherford Regional Health System, Rutherford, NC, USA.
*Corresponding Author: Azadeh Khayyat, Email: akhayyat@mcw.edu, Email: akhayyat@mcw.edu


Cinacalcet has emerged as an effective therapeutic option for the management of secondary hyperparathyroidism (SHPT) and chronic kidney disease-mineral and bone disorder (CKD-MBD). Through its modulation of the calcium-sensing receptor (CaSR), cinacalcet demonstrates considerable clinical benefits in maintaining parathyroid hormone and serum calcium levels within target ranges. It offers a valuable addition to the available treatment options for patients with these conditions. Cinacalcet binds to the CaSR on parathyroid cells, increasing its sensitivity to extracellular calcium. This results in decreased parathyroid hormone (PTH; parathormone), release through inhibition of intracellular signaling pathways involved in PTH synthesis and secretion. Cinacalcet also indirectly reduces serum calcium and phosphorus levels by suppressing PTH-mediated bone resorption and enhancing renal phosphate excretion.

Please cite this paper as: Khayyat A, Esmaeil Pour MA. Clinical administration of cinacalcet in parathyroid diseases. J Parathyr Dis. 2024;12:e11256. doi:10.34172/jpd.2024.11256.
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Submitted: 20 Dec 2023
Accepted: 10 Feb 2024
ePublished: 17 Feb 2024
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