J Parathyr Dis. 2024;12: e11259.
doi: 10.34172/jpd.2024.11259
  Abstract View: 91
  PDF Download: 79


Recent advancements in the treatment of tertiary hyperparathyroidism

Parisa Tajdini 1* ORCID logo, Simin Mazaheri Tehrani 2 ORCID logo, Yasaman Vahdani 3* ORCID logo

1 Clinical Research Development Unit, Amir-Al-Momenin Educational, Research and Therapeutic Hospital, Semnan University of Medical Sciences, Semnan, Iran.
2 Department of Molecular Biotechnology and Health Sciences, School of Medicine, University of Turin, Turin, Italy.
3 Department of Biochemistry and Molecular Medicine, University of Montreal, Canada.
*Corresponding Authors: Parisa Tajdini, Email: ptajedini@gmail.com; Yasaman Vahdani, Email: yasaman.vahdani@umontreal.ca


Tertiary hyperparathyroidism is a condition characterized by excessive production of parathyroid hormone (PTH) by the parathyroid glands, leading to increased calcium levels in the blood. It typically occurs in patients with long-standing secondary hyperparathyroidism, often as a result of chronic kidney disease (CKD). The primary treatment goal for tertiary hyperparathyroidism is to normalize PTH levels and maintain calcium and phosphorus balance. This typically involves the use of medications to control hypercalcemia and hyperphosphatemia. Calcimimetic agents, such as cinacalcet, can help lower PTH levels by increasing the sensitivity of the calcium-sensing receptors on the parathyroid glands. Additionally, phosphate binders can be prescribed to reduce serum phosphate levels.

Please cite this paper as: Tajdini P, Mazaheri Tehrani S, Vahdani Y. Recent advancements in the treatment of tertiary hyperparathyroidism. J Parathyr Dis. 2024;12:e11259. doi:10.34172/jpd.2024.11259.
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Submitted: 13 Feb 2024
Accepted: 26 Apr 2024
ePublished: 01 Jun 2024
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