Logo-jpd
J Parathyr Dis. 2024;12: e12262.
doi: 10.34172/jpd.2024.12262
  Abstract View: 173
  PDF Download: 128

Original

Risk of bone fractures in patients with primary hyperparathyroidism: a systematic review and meta-analysis

Yashar Shahbaz 1 ORCID logo, Zahra Jamalafrouz 2 ORCID logo, Nazanin Hesari 3 ORCID logo, Reza Noktehsanj 4 ORCID logo, Mobin Forghan 4 ORCID logo, Kiarash Tohidi 5 ORCID logo, Amin Norouzbeygi 6 ORCID logo, Seyed Shahab Aldin Vaziri 7 ORCID logo, Reza Asadi 6* ORCID logo

1 Orthopedic Research Center, Shahid Kamyab Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Department of Nursing, Faculty of Nursing and Midwifery, Mashhad Medical Sciences, Islamic Azad University Mashhad, Iran.
3 Department of Midwifery, School of Nursing and Midwifery, North Khorasan University of Medical Sciences, Bojnurd, Iran.
4 Department of Surgery and Orthopedic, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
5 Department of Orthopedic, Fatemi Medical Center, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
6 Department of Orthopedic and Trauma Surgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
7 Department of Orthopedic, Imam Khomeini Hospital, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
*Corresponding Author: Reza Asadi, Email: rezamry88@gmail.com

Abstract

Introduction: Primary hyperparathyroidism, a prevalent endocrine disorder, is known to cause osteoporosis. This study aims to examine the association between primary hyperparathyroidism and the risk of bone fracture.

Materials and Methods: A systematic review and meta-analysis approach was employed in this article. The databases ProQuest, PubMed, Web of Science, Cochrane, and the search engine Google Scholar were searched up to June 20, 2023. Data analysis was conducted applying STATA 14 software.

Results: Primary hyperparathyroidism increased the risk of any fractures overall (OR: 1.45, 95% CI: 1.26–1.67) in patients aged 50-59 years (OR: 1.37, 95% CI: 1.18–1.60) and in those aged 60-69 years (OR: 1.60, 95% CI: 1.25–2.05). Moreover, primary hyperparathyroidism led to an increased risk of vertebral fracture (OR: 1.90, 95% CI: 1.12–3.22), foot fracture (OR: 1.55, 95% CI: 1.09–2.20), femur fracture (OR: 1.51, 95% CI: 1.16–1.96), and osteoporotic fracture (OR: 1.42, 95% CI: 1.24–1.64). However, no statistically significant association was reported between primary hyperparathyroidism and the risk of hip fracture (OR: 1.11, 95% CI: 0.90–1.38), hand fracture (OR: 1.55, 95% CI: 0.88–2.75), forearm fracture (OR: 1.51, 95% CI: 0.52–4.39), femoral neck fracture (OR: 1.12, 95% CI: 0.56–2.25), and cervical fracture (OR: 1.40, 95% CI: 0.63–3.13).

Conclusion: The risk of any fractures in patients with primary hyperparathyroidism was 45% higher than in healthy individuals and increased with advancing age. Furthermore, primary hyperparathyroidism elevated the risk of vertebral fracture by 90%, foot fracture by 55%, femur fracture by 51%, and osteoporotic fracture by 42%.

Registration: This study has been compiled based on the PRISMA checklist, and its protocol was registered on the PROSPERO (ID: CRD42024563393) and Research Registry (UIN: reviewregistry1851) websites.


Please cite this paper as: Shahbaz Y, Jamalafrouz Z, Hesari N, Noktehsanj R, Forghan M, Tohidi K, Norouzbeygi A, Vaziri SSh, Asadi R. Risk of bone fractures in patients with primary hyperparathyroidism: a systematic review and meta-analysis. J Parathyr Dis. 2024;12:e12262. doi:10.34172/jpd.2024.12262.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 174

Your browser does not support the canvas element.


PDF Download: 128

Your browser does not support the canvas element.

Submitted: 05 Aug 2024
Accepted: 04 Oct 2024
ePublished: 02 Nov 2024
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)