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J Parathyr Dis. 2025;13: e13302.
doi: 10.34172/jpd.2025.13302
  Abstract View: 34
  PDF Download: 13

Review

Inflammatory impact of cigarette smoking on bone function and structure; a review of evidence

Yashar Shahbaz 1 ORCID logo, Rasoul Shirmohammadi 2 ORCID logo, Shirin Shamsghahfarokhi 3 ORCID logo, Hooman Esfahani 4 ORCID logo, Mobin Forghan 5 ORCID logo, Hojjat Eghbali Jelodar 5 ORCID logo, Leila Ashrafi 6 ORCID logo, Mohammad Mousavi 6* ORCID logo

1 Orthopedic Research Center, Shahid Kamyab Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Department of Orthopaedic Surgery, Sina Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
3 Department of Internal Medicine, School of Medicine, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran.
4 Department of Emergency Medicine, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
5 Department of Surgery and Orthopedic, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
6 Department of Internal Medicine, Clinical Research Development Unit, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran.
*Corresponding Author: Mohammad Mousavi, Email: M_mousavi50@yahoo.com

Abstract

Cigarette smoking represents a major lifestyle risk factor for bone loss and skeletal disorders, with complex etiological mechanisms consisting both direct tissue effects and systemic alterations. Recent evidence demonstrates that tobacco smoking triggers an intricate cascade of cellular and molecular events that disrupts the delicate balance of bone remodeling, finally leading to decreased bone mass and increased fracture risk.

Please cite this paper as: Shahbaz Y, Shirmohammadi R, Shamsghahfarokhi Sh, Esfahani H, Forghan M, Eghbali Jelodar H, Ashrafi L, Mousavi M. Inflammatory impact of cigarette smoking on bone function and structure; a review of evidence. J Parathyr Dis. 2025;13:e13302. doi:10.34172/jpd.2025.13302.
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Submitted: 06 Jul 2025
Revision: 16 Aug 2025
Accepted: 27 Aug 2025
ePublished: 03 Sep 2025
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