Nickan Research Institute Journal of Parathyroid Disease 2345-6558 11 1 2023 01 01 Relationship between Klotho and parathormone e11230 e11230 10.34172/jpd.2023.11230 EN Azar Baradaran https://orcid.org/0000-0001-7058-6367 Journal Article 10.34172/jpd.2023.11230 2023 05 11 2023 07 18 Klotho is a protein that has been found to play a role in regulating parathyroid hormone (PTH) levels. The literature suggests an intricate relationship between Klotho and PTH. Klotho acts as a co-receptor for fibroblast growth factor 23 (FGF23), a hormone that helps regulate phosphate and vitamin D metabolism. Klotho deficiency has been associated with increased PTH levels and secondary hyperparathyroidism. Several studies have investigated the relationship between Klotho and PTH levels. Some studies have shown that Klotho levels are inversely correlated with PTH levels, suggesting that higher Klotho levels may lead to lower PTH levels. Other studies have found that Klotho deficiency can contribute to PTH resistance, leading to persistent hyperparathyroidism. Additionally, the Klotho-PTH axis holds promise as a potential target for therapeutic interventions in calcium and phosphate disorders.