Nickan Research Institute Journal of Parathyroid Disease 2345-6558 11 1 2023 01 01 Mechanistic impact of fibrosis by parathyroid hormone excess 11231 11231 10.34172/jpd.2023.11231 EN Azar Baradaran https://orcid.org/0000-0001-7058-6367 Journal Article 10.34172/jpd.2023.11231 2023 05 11 2023 07 18 The fibrotic impact of parathyroid hormone (PTH) excess is an important aspect of primary hyperparathyroidism (PHPT) that can contribute to organ dysfunction and morbidity. Understanding the underlying mechanisms of PTH-induced fibrosis and identifying potential therapeutic targets may pave the way for novel treatment strategies. Further research is needed to elucidate the complex interactions between PTH and fibrotic pathways and to evaluate the efficacy of targeted interventions in preventing or reversing fibrosis associated with PHPT. The fibrotic impact of PTH excess is observed across multiple organ systems. Fibrosis resulting from PTH excess can impair organ function and lead to significant morbidity and mortality. Understanding the underlying mechanisms involved in PTH-induced fibrosis is crucial for developing targeted therapies to mitigate its detrimental effects.