Nickan Research Institute Journal of Parathyroid Disease 2345-6558 14 1 2026 01 01 Decoding immunoporosis-novel insights into immune system dysregulation in bone health and disease e13327 e13327 10.34172/jpd.13327 EN Aysuliu Sharopova https://orcid.org/0009-0008-8781-8054 Nodira Shukurova https://orcid.org/0009-0003-8946-1670 Maftuna Aliyeva https://orcid.org/0009-0003-5660-492X Gulshod Usmonova https://orcid.org/0000-0001-7247-8386 Zulfiya Davlyatova https://orcid.org/0009-0005-8594-5998 Munira Payziyeva https://orcid.org/0009-0000-1400-7287 Iroda Tishabayeva https://orcid.org/0009-0001-3081-8917 Fayzulla Yuldashov https://orcid.org/0009-0007-9226-9857 Tulkin Elmurodov https://orcid.org/0009-0002-4223-4334 Adkhambek Nurboboyev https://orcid.org/0000-0002-3835-2445 Journal Article 10.34172/jpd.13327 2025 05 03 2026 06 27 Immunoporosis represents a novel field that investigates the crucial role of immune system dysregulation in bone health and disease, particularly in conditions like osteoporosis. Traditionally, osteoporosis has been viewed primarily as a bone remodeling disorder influenced by factors such as estrogen deficiency or aging. However, recent advancements in osteoimmunology have highlighted the extensive communication between bone and the immune system in maintaining skeletal homeostasis. The term immunoporosis emphasizes on the significant impact of immune cells and inflammatory factors on the pathophysiology of osteoporosis. This paradigm shift recognizes osteoporosis as a chronic immune-mediated disease. The immune system influences bone remodeling and regulates bone mass through the production of various cytokines, chemokines, and growth factors. Inflammatory bone conditions, including osteoporosis, often arise from a dysregulation in the intricate balance between the bone and immune systems. Both innate and adaptive immune cells and their secretory cytokines are crucial players in skeletal homeostasis. For instance, immune cells can directly influence bone health, and the dysregulation of immune function can lead to abnormal bone conditions. The interplay between these systems offers promising avenues for developing immunomodulatory treatments for osteoporosis and other bone pathologies.