Nickan Research Institute Journal of Parathyroid Disease 2345-6558 9 1 2021 01 01 Relationship between body mass index and bone mineral density in Mashhad, Iran; a cross-sectional Study e03 e03 EN Nayyereh Saadati https://orcid.org/0000-0002-4589-8091 Maryam Miri https://orcid.org/0000-0002-9962-6753 Journal Article 2020 05 19 2020 08 06 Introduction: There is controversy regarding the effect of body weight on bone mineral density (BMD). Objectives: The aim of this study was to assess the relationship between body mass index (BMI) and BMD among a sample of Iranian citizens. Patients and Methods: This cross-sectional study was conducted on Iranian citizens who referred to Ghaem Hospital, Mashhad, Iran for bone densitometry. Measurements included weight, height, BMI and dual X-ray absorptiometry (DEXA) parameters including femoral T-score (FT) and Z-score (FZ) and lumbar spine T-score (LT) and Z-score (LZ). Data were analyzed using the statistical package for social sciences (SPSS) software version 22. Results: A total of 302 subjects (15.2% male and 84.8% female) with the mean age of 55.15 ± 12.03 years participated in the study. The prevalence of osteopenia based on TF and TL was 2.3% and 3.0% respectively. The prevalence of osteoporosis based on TF and TL was 1.0% and 3.0% respectively. Age was significantly correlated with TL and ZL (r=-0.17, P=0.002 and r=-0.12, P=0.037 respectively). BMI was significantly interrelated with TF (r=0.17, P=0.009) and ZF (r=0.20, P=0.02). FT was significantly correlated with age (r=-0.12, P=0.045). TL was significantly higher in <40 years group compared to >55 years group (P=0.003).TF was significantly higher in <40 years group compared to >55 years group (P=0.030). BMI was significantly correlated with FZ among post-menopausal women (r=0.34, P<0.001). Conclusion: This study showed that higher BMI was associated with higher FT and FZ while only FZ was correlated with BMI among post-menopausal women.