Parathyroid hormone abnormities in sickle cell anemia patients

Abstract

Sickle cell anemia (SCA) is an inherited autosomal recessive blood disorder, characterized by the presence of sickle hemoglobin (HbS) that imparts sickle shape to RBC under low oxygen tension. SCA is a fatal multisystem disorder that exhibits extraordinary degree of phenotypic variability. Despite the high mortality and morbidity associated with complication in SCA patients, there is limited information on the abnormalities of parathyroid hormone (PTH). Therefore, the purpose of this study was to describe the abnormalities of PTH in SCA patients. We searched Medline, Embase, the Cochrane Library, and observational studies relating to the parathyroid hormone, PTH, hyperparathyroidism and SCA. The hypocalcemia found in SCA patient is thought to be a reflection of parathyroid gland abnormalities and failure to activate vitamin D. This information will help future research and eventually will improve diagnosis, prognosis, and management of PTH abnormities in SCA patients.