J Parathyr Dis. 2019;7: 7.
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The effect of iron on vitamin D level in children with combined iron and vitamin D deficiency

Noushin Rostampour 1,2, Seyed Mohammad Kazem Nourbakhsh 3*, Narges Navabfar 4, Mohammad Bahadoram 5

1 Department of Pediatric Endocrinology, Shahrekord University of Medical Sciences, Shahrekord, Iran.
2 Department of Pediatric endocrinology, Isfahan University of Medical Sciences, Isfahan, Iran.
3 Department of Pediatric Hematology and Oncology, Imam Hospital, Tehran University of Medical Sciences, Tehran, Iran.
4 Department of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran.
5 Medical Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
*Corresponding Author: *Corresponding author: Seyed Mohammad Kazem Nourbakhsh; Email address: , Email: dr.nourbakhsh2010@gmail.com


Introduction: Iron deficiency (ID) and vitamin D deficiency (VDD) are two common nutritional problems. Recently, an association between these two disorders has been suggested that remains to be definitely confirmed.Objectives: Our aim was to compare treatment with iron, vitamin D, and their combination on serum levels of vitamin D in children with ID and vitamin D insufficiency (VDI).

Patients and Methods: A total of 90 patients with low levels of ferritin and vitamin D were assigned to three groups of 30 each: treatment with iron for ID, treatment with vitamin D, and co-treatment with vitamin D and iron. Levels of vitamin D and ferritin were measured before and 3 months after treatment. Data analysis was entirely conducted by paired t-test, one-way ANOVA using SPSS 19.

Results: Serum vitamin D levels significantly changed 3 months after treatment in the vitamin D and iron+ vitamin D groups (P < 0.01), but not in the iron group (P = 0.68). Comparison of mean changes in serum vitamin D levels was not significantly different between the iron+ vitamin D and vitamin D groups (P = 0.774).

Conclusion: Iron supplementation alone could not significantly increase vitamin D levels in studied children. Vitamin D supplementation and vitamin D+ iron supplementation caused similar effects on serum vitamin D levels, and management of ID did not have any incremental effect on vitamin D levels in children. It is necessary to use vitamin D supplementation to control and treat VDD.


Please cite this paper as: Rostampour N, Nourbakhsh SMK, Navabfar N, Bahadoram M. The effect of iron on vitamin D level in children with combined iron and vitamin D deficiency. J Parathyr Dis. 2019;7:7-12.
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ePublished: 02 Aug 2018
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