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J Parathyr Dis. 2023;11: e11202.
doi: 10.34172/jpd.2023.11202
  Abstract View: 661
  PDF Download: 380

Clinical Trial

Serum uric acid-reduction and blood pressure changes in allopurinol administered hemodialysis patients; a pilot study

Saeed Mardani 1 ORCID logo, Hossein Mardanparvar 2 ORCID logo, Mahnaz Momenzadeh 3* ORCID logo, Seyedeh Fatameh Nourbakhsh Rezaiee 1, Mohammad Reza Hajian 3 ORCID logo

1 Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
2 Department of Nursing, Faculty of Nursing and Midwifery, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
3 Nickan Research Institute, Isfahan, Iran.
*Corresponding Author: Corresponding author: Mahnaz Momenzadeh, Email: Mahnazmomenzadehf@gmail.com, , Email: Mahnaz.momenzadeh@pharm.mui.ac.ir

Abstract

Introduction: Hypertension is one of the most common diseases and is the main cause of disability and mortality worldwide. Hyperuricemia has been recognized as one of the main causes of hypertension; however, few studies have been conducted to determine the correlation between serum uric acid reduction and blood pressure changes.

Objective: This study aimed to assess the correlation between serum uric acid-reduction and blood pressure changes in a group of hemodialysis patients.

Patients and Methods: This descriptive-analytical study was conducted on 21 hemodialysis patients taking allopurinol for the first time. Serum uric acid, systolic blood pressure, and diastolic blood pressure were measured before taking allopurinol, then patients were followed for two months, and these parameters were remeasured. Data were collected and the correlation between serum uric acid-reduction and blood pressure changes was evaluated.

Results: Most patients were female, with a mean age of 56.81 ± 15.59 years. Results showed that the correlation between serum uric acid reduction and blood pressure changes was statistically significant with a ratio of 3.6 reduction for systolic blood pressure and 2.17 for diastolic blood pressure per one unit of uric acid reduction (P<0.05).

Conclusion: Uric acid reduction is correlated with blood pressure reduction with both systolic and diastolic blood pressures.


Please cite this paper as: Mardani S, Mardanparvar H, Momenzadeh M, Nourbakhsh Rezaiee SF, Hajian MR. Serum uric acid-reduction and blood pressure changes in allopurinol administered hemodialysis patients; a pilot study. J Parathyr Dis. 2023;11:e11202. doi:10.34172/ jpd.2023.11202. Copyright © 2023
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Submitted: 13 Jan 2023
Accepted: 10 Apr 2023
ePublished: 15 Apr 2023
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