J Parathyr Dis. 2023;11: e11230.
doi: 10.34172/jpd.2023.11230
  Abstract View: 244
  PDF Download: 114


Relationship between Klotho and parathormone

Azar Baradaran* ORCID logo

1 Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding Author: Azar Baradaran, Email: azarbaradaran@med.mui.ac.ir, , Email: azarbaradaran@yahoo.com


Klotho is a protein that has been found to play a role in regulating parathyroid hormone (PTH) levels. The literature suggests an intricate relationship between Klotho and PTH. Klotho acts as a co-receptor for fibroblast growth factor 23 (FGF23), a hormone that helps regulate phosphate and vitamin D metabolism. Klotho deficiency has been associated with increased PTH levels and secondary hyperparathyroidism. Several studies have investigated the relationship between Klotho and PTH levels. Some studies have shown that Klotho levels are inversely correlated with PTH levels, suggesting that higher Klotho levels may lead to lower PTH levels. Other studies have found that Klotho deficiency can contribute to PTH resistance, leading to persistent hyperparathyroidism. Additionally, the Klotho-PTH axis holds promise as a potential target for therapeutic interventions in calcium and phosphate disorders.

Please cite this paper as: Baradaran A. Relationship between Klotho and parathormone. J Parathyr Dis. 2023;11:e11230. doi:10.34172/ jpd.2023.11230.
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Submitted: 11 May 2023
Accepted: 18 Jul 2023
ePublished: 14 Aug 2023
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