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J Parathyr Dis. 2023;11: 11231.
doi: 10.34172/jpd.2023.11231
  Abstract View: 370
  PDF Download: 292

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Mechanistic impact of fibrosis by parathyroid hormone excess

Azar Baradaran* ORCID logo

1 Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding Author: Azar Baradaran, Email: azarbaradaran@med.mui.ac.ir, , Email: azarbaradaran@yahoo.com

Abstract

The fibrotic impact of parathyroid hormone (PTH) excess is an important aspect of primary hyperparathyroidism (PHPT) that can contribute to organ dysfunction and morbidity. Understanding the underlying mechanisms of PTH-induced fibrosis and identifying potential therapeutic targets may pave the way for novel treatment strategies. Further research is needed to elucidate the complex interactions between PTH and fibrotic pathways and to evaluate the efficacy of targeted interventions in preventing or reversing fibrosis associated with PHPT. The fibrotic impact of PTH excess is observed across multiple organ systems. Fibrosis resulting from PTH excess can impair organ function and lead to significant morbidity and mortality. Understanding the underlying mechanisms involved in PTH-induced fibrosis is crucial for developing targeted therapies to mitigate its detrimental effects.

Please cite this paper as: Baradaran A. Mechanistic impact of fibrosis by parathyroid hormone excess. J Parathyr Dis. 2023;11:e11231. doi:10.34172/jpd.2023.11231.
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Submitted: 11 May 2023
Accepted: 18 Jul 2023
ePublished: 14 Aug 2023
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