Aysuliu Sharopova
1* 
, Nodira Shukurova
2 , Maftuna Aliyeva
3 , Gulshod Usmonova
4 , Zulfiya Davlyatova
5 , Munira Payziyeva
6 , Iroda Tishabayeva
7 , Fayzulla Yuldashov
8 , Tulkin Elmurodov
9 , Adkhambek Nurboboyev
10 1 Department of 1st Faculty and Hospital Therapy, Rheumatology and Occupational Pathology, Tashkent State Medical University, Tashkent, Uzbekistan.
2 Department of Therapeutic Stomatology, Samarkand State Medical University, Samarkand, Uzbekistan.
3 Department of Oncology, Andijan State Medical Institute, Andijan, Uzbekistan.
4 Bukhara State University, Bukhara, Uzbekistan.
5 Fergana State Technical University, 86 Fergana Street, Fergana 150107, Uzbekistan.
6 Department of Higher Mathematics, Tashkent University of Information Technologies named after Muhammad al-Khwarizmi, Tashkent 100200, Uzbekistan.
7 Department of Social Sciences and Sports, Ferghana State Technical University, Ferghana, Uzbekistan.
8 Department of Urology and Oncology, Fergana Medical Institute of Public Health, Fergana, Uzbekistan.
9 Department of Mining Work, Tashkent State Technical University named after Islam Karimov, Tashkent, Uzbekistan.
10 Department of General Surgery, Bukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara, Uzbekistan.
Abstract
Immunoporosis represents a novel field that investigates the crucial role of immune system dysregulation in bone health and disease, particularly in conditions like osteoporosis. Traditionally, osteoporosis has been viewed primarily as a bone remodeling disorder influenced by factors such as estrogen deficiency or aging. However, recent advancements in osteoimmunology have highlighted the extensive communication between bone and the immune system in maintaining skeletal homeostasis. The term immunoporosis emphasizes on the significant impact of immune cells and inflammatory factors on the pathophysiology of osteoporosis. This paradigm shift recognizes osteoporosis as a chronic immune-mediated disease. The immune system influences bone remodeling and regulates bone mass through the production of various cytokines, chemokines, and growth factors. Inflammatory bone conditions, including osteoporosis, often arise from a dysregulation in the intricate balance between the bone and immune systems. Both innate and adaptive immune cells and their secretory cytokines are crucial players in skeletal homeostasis. For instance, immune cells can directly influence bone health, and the dysregulation of immune function can lead to abnormal bone conditions. The interplay between these systems offers promising avenues for developing immunomodulatory treatments for osteoporosis and other bone pathologies.