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Case Report

Interference caused by anti-streptavidin antibodies in a parathyroid hormone assay; a case report

Benjamin Siegfried Trautz 1* ORCID logo, Thomas Negele 1

1 Martha-Maria Hospital, Munich, Germany.
*Corresponding author: Benjamin Siegfried Trautz, Email: b.trautz@web.de

Abstract

Endogenous antibodies can lead to test interference in streptavidin-biotin based laboratory assays, such as thyroid function tests or parathyroid hormone (PTH) levels. We report about a patient, who presented for thyroid surgery, showing undetectable PTH levels despite normocalcaemia in internally assessed preoperative laboratory work. Previously, anti-streptavidin antibodies were detected in the patient’s blood and normal PTH levels could be measured in a streptavidin-free assay. To our knowledge this is the first reported case of a clinically relevant PTH test interference due to endogenous anti-streptavidin antibodies, thus complicating the evaluation of postoperative hypoparathyroidism.
Keywords: PTH, Anti-streptavidin, Thyroid surgery, Hypoparathyroidism, Interference, TSH
Please cite this paper as: Trautz BS, Negele T. Interference caused by anti-streptavidin antibodies in a parathyroid hormone assay; a case report. J Parathyr Dis. 2022;10:e01.
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Submitted: 02 Jul 2021
Accepted: 31 Jul 2021
ePublished: 08 Aug 2021
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